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Loss of CXCL10 does not alter astrocyte reactivity, but instead, reduces demyelination, microglial reactivity, and axonal damage after three weeks of cuprizone diet [186], thus linking this astrocyte-derived chemokine to microglia recruitment and demyelination (Fig

The combination of arsenic disulfide and itraconazole has a synergistic effect, jointly downregulating the expression of SMO and Glil proteins in the Hedgehog signaling pathway to achieve anti-tumor effects (Wang et al., 2021b)