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Evidence for a role of glucuronosyltransferase in the regulation of androgen action in the human prostatic cancer cell line LNCaP

Abbreviations PsA: Psoriatic arthritis PsO: Psoriasis RA: Rheumatoid arthritis HC: Healthy control CASPAR: ClASsification for psoriatic ARthritis DAPSA: Disease activity PsA PCA: Principal component analysis OPLS-DA: Orthogonal partial least squares discriminant analysis VIP: Variable influence on projection ROC: Receiver operator characteristic curves AUC: Area under the curve DT2: Diabetes type 2 BCAAs: Branched-chain amino acids CRP: C-reactive protein GSH: Glutathione Trp: Tryptophan References Ritchlin, C

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Under resting conditions, ASC is S-glutathionylated (notably at Cys171), a modification that impairs ASC oligomerization and prevents spontaneous inflammasome formation 67

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Mitochondrial dynamics and cancer