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These experiments indicated that, in addition to requiring Cys-dependent de novo biosynthesis of GSH for survival (see above), TrxR1/Gsr-null livers require de novo biosynthesis of Cys via transsulfuration, and that they cannot effectively utilize cystine as a hepatic Cys source [107]
Indeed, several clinical inflammatory conditions have been associated with lower levels of glutathione
C.AgarwalV.LettieriJ.SundaresenP
Pereira, L., Cotas, J., & Valado, A
Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS, ACTS Study Group
Finally, the phylogenetic analysis showed a high level of diversity of cestodes GSTs
