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Specifically, CGRP upregulates vascular endothelial growth factor A (VEGF-A) expression, while SP upregulates angiopoietin 1 (Angpt1), collagen type IV (Col IV), and matrix metalloproteinase 2 (MMP2) expression (147)

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The peptide specifically upregulates genes for both type I collagen, which provides structural strength, and type III collagen, which contributes to tissue flexibility and elasticity

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J Toxicology Environ Health, Part B 26:442467 Rahman MT (2023) Mechanisms of immune responses