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Nuttall et al.[37] studied the effect of chronic ingestion of therapeutic doses of APAP (1 gram, 4 times per day, for 2 weeks) on serum antioxidant capacity, and found a gradual and progressive decline to a level about 85% of control value

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It has been demonstrated that mutant SOD1 accumulates in the mitochondrial membrane gap, thereby reducing the activity of the electron transport chain (ETC) complex

Alimentary Pharmacology & Therapeutics, 12 (12), 1279-1289

doi: 10.1016/j.tifs.2018.05.012 43

We examined their molecular mechanisms of action and discussed the therapeutic implications of incorporating these natural agents into clinical practice