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The protocol successfully generated hepatocytes from cGMP cell lines using small molecules combined with growth factors in 21 days ( ALB expression was detected but insignificant in the induced hepatocytes, suggesting that the hepatocytes was immature ( ALB positive hepatocytes account for 67.7% versus 37.1% in the growth factor group ( 3.2 Small molecules for direct reprogramming to hepatic lineage Recently, studies have shown that somatic cells can be directly reprogrammed into specific cell lineage, including hepatocytes

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With its excellent safety profile and ease of administration, epithalon may be administered twice annually in two short courses for its anti-aging effects

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