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ADGRD1 (GPR133), ADGRG1 (GPR56), and ADGRG5 (GPR114) sense mechanical forces through their N-terminal extracellular domain, thereby participating in cell-cell contact and maintaining cellular homeostasis [5759]
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Absolute contraindications include personal or family history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2 (MEN 2)
