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Immunometabolic reprogramming: Enhancing SLC38A2 expression in type 1 conventional dendritic cells (cDC1s) may improve glutamine uptake and potentially reverse antigen presentation defects

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Binding of released Bim to Mcl-1 is a mechanism of intrinsic resistance to ABT-199 which can be Overcome by combination with daunorubicin or cytarabine in AML cells

Common side effects: Injection site reactions (redness, itching, pain) most common, typically mild and transient Fluid retention or peripheral edema particularly in the first few weeks of treatment Joint pain (arthralgia) or myalgia Paresthesia (tingling sensations, often in extremities) Metabolic considerations: GH can cause mild increases in fasting glucose

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Sufficient clinical evidence is available to recommend the use of NAC or carbocisteine as an addition to current therapies in certain patients with COPD, at least in the hope of reducing the number of respiratory exacerbations and possibly improving the health-related quality of life