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For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]

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Possible side effects may include mild gastrointestinal upset, headache, or temporary discoloration of urine

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10.1111/anec.12158 106