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Lipogenesis Inhibition: In adipose tissue, NNMT inhibition reduces lipid accumulation by up to 70% (in vitro), shifting the cell's priority from fat storage to energy expenditure

Appropriate caution should be exercised while treating severe megaloblastic anemia with cyanocobalamin as intense treatment may lead to hypokalemia and sudden death

No human study has tested these combinations

Mechanism of Action AOD-9604 works by: Activating beta-3 adrenergic receptors Triggering lipolysis (breakdown of stored fat) Inhibiting lipogenesis (formation of new fat cells) Result: Safe, steady loss of body fat even in stubborn areas like the abdomen, thighs, chin, and arms

doi:10.1016/j.drudis.2021.07.009
