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Physical therapy, speech therapy, and occupational therapy are also recommended to improve quality of life and slow disease progression

However, NADK has recently been shown to be a direct target of AKT kinase, phosphorylating the residues Ser44, Ser46 and Ser48 and leading to enhanced activation of NADK 271

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This adaptive thermogenesis can slow weight loss over time and, if caloric intake isn't adjusted accordingly, may contribute to weight stabilization or modest regain