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Bortezomib, an FDA-approved proteasome inhibitor used primarily in cancer treatment, has demonstrated potential in blocking NF-kB activation and may be explored for emphysema

While Mn-SOD-deficient mice exhibit heart hypertrophy and fibrosis, Mn-SOD overexpression has been found to suppress cardiac fibrosis in aged mice

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doi: 10.1371/journal.pone.0092980

[DOI] [PMC free article] [PubMed] [Google Scholar] 234.Petillon C., Hergesheimer R., Puy H., Corcia P., Vourch P., Andres C., Karim Z., Blasco H

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