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Loss of polarity protein AF6 promotes pancreatic cancer metastasis by inducing Snail expression

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Then -catenin binds to a protein called TrCP (beta-transducin repeat containing protein) that mediates the ubiquitination of CTNNB1 and the proteins tagged with ubiquitin are degraded by the proteosome that results in -catenin destruction by the proteosomal degradation

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doi: 10.1021/tx9003402

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Gut dysbiosis is characterized by the excessive growth of harmful bacteria, leading to the increased release of substances such as LPS, peptidoglycans, bacterial DNA, and outer membrane proteins into the bloodstream of the host

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