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In addition to the role mentioned above in the process of oxidative stress, the GPX family also plays a unique role in tumor development ( Statements Author contributions All authors listed have made a substantial, direct, and intellectual contribution to the work and approved it for publication

Vitamin B12 is used for Maintaining the health of the nerves in the body

Low blood levels of vitamin B12 have been linked with decreased bone mass

We propose that NADPH and GSSG convey TCA cycle status: decreasing the availability of acetyl-CoAeither from lipid or carbohydrate catabolismdampens NADPH production and disfavors glutathione reduction, with the increased GSSG ultimately rendering the ER lumen more oxidizing and protecting ER homeostasis

Nutr Res Rev 9:312315 Fairweather-Tait SJ, Bao Y, Broadley MR, Collings R, Ford D, Hesketh JE, Hurst R (2011) Selenium in human health and disease

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