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These compounds mitigate tissue damage and alleviate symptoms associated with AR by inhibiting inflammatory mediators, oxidative stress, and apoptosis

Clinical trials are needed to validate antagonist efficacy and safety

[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Braniste V., Leveque M., Buisson-Brenac C., Bueno L., Fioramonti J., Houdeau E

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Briefly, at typical physiological GSH concentrations and pH, the reaction between ONOO - and GSH will predominantly be a two electron oxidation process leading to GSSG formation (Quijano et al., 1997)