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Eighty quails were divided into four groups, with the experimental groups receiving 15, 30 or 60 mg/kg of ZnONPs over 60 days (ElBahr et al

"NRF2 activation renders cells resistant to chemical carcinogens and inflammatory challenges." "NRF2 activity is tightly regulated through a complex transcriptional and post-translational network that enables it to orchestrate the cells response and adaptation to various pathological stressors for the homeostasis maintenance." - Source

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However, in certain cases, this epigenetic modification can induce the transition of microglia to the M2 repair phenotype when lactate levels are increased [47]

doi: 10.1038/ncomms10690 11 SharmaSLeeDLiBQuinlanMTakahashiFMaheswaranSet al