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Crosstalk-driven vicious cycles: the interplay of oxidative stress, chronic inflammation, and mitochondrial impairment in ME/CFS The oxidative stress-inflammation feedback loop in ME/CFS Under normal physiological conditions, the immune system maintains the balance of ROS and RNS, which are important for cell signaling and effective immune responses [88, 89]

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Breathe two slow breaths into their lungs, making sure the chest rises (if available, use rescue breathing barrier device, pocket mask, or face shield)