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https saf.wellsfargoadvisors.com emx dctm research asg dsip xel_dsip_emx.pdf SNAPSHOT Current period ending August 31, 2020 Message from Wells Fargo Advisors Investor Behavior

In OPERA I and OPERA II, the annualized relapse rate was 46% and 47% lower, respectively, in the ocrelizumab group compared to the interferon beta-1a group

https saf.wellsfargoadvisors.com emx dctm research asg dsip xel_dsip_emx.pdf SNAPSHOT Current period ending August 31, 2020 Message from Wells Fargo Advisors Investor Behavior

Inspect the pen and ensure the solution is clear and colourless Prime the pen on first use until a drop appears Dial the required dose (clicks) Apply to clean skin (abdomen or thigh) Hold in place for 6 seconds Replace the cap and store properly 12 clicks = 5 mg Use once daily Typically used for up to 20 consecutive days Follow with a 2-week break before restarting Adjust under professional guidance Approximately 20 doses per pen (based on 5 mg daily use)

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Paul of the Cross is committed to student achievement by sharing knowledge and best practices to provide students with support and differentiated learning experiences in the general education classroom

https saf.wellsfargoadvisors.com emx dctm research asg dsip xel_dsip_emx.pdf SNAPSHOT Current period ending August 31, 2020 Message from Wells Fargo Advisors Investor Behavior

Its given intramuscularly (IM) or subcutaneously

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Symptoms like inflammation and pain may not get better immediately

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