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We did not investigate other aspects of tau pathology such as aggregation, phosphorylation, or downstream signaling cascades

This should be job one

23 In addition, these peptides may indirectly regulate AMPK activity to promote mitochondrial efficiency and FoxO transcription factors (Table 2)

Gratzl, S., Rodriguez, P

doi: 10.1186/s43162-024-00331-7

So thats exciting that that synergy exists
