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Beneficial pleiotropic actions of melatonin in an experimental model of septic shock in mice: regulation of pro-/anti-inflammatory cytokine network, protection against oxidative damage and anti-apoptotic effects

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Damage to the intestinal barrier is hypothesized to allow large molecules, such as gluten and casein, to enter the bloodstream, thereby triggering the release of pro-inflammatory cytokines (e.g., IL-6 and TNF-), which may adversely affect neural function through the opioid system

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[DOI] [PubMed] [Google Scholar] 40.Vollmer K, Gardiwal H, Menge BA, Goetze O, Deacon CF, Schmidt WE, et al