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We conclude that intracellular pyruvate, or other -ketoacids, whose endogenous concentration is controlled by metabolism, have little role in H2O2 clearance

Cystinotic patients have been shown to excrete in their urine high levels of pyroglutamate, an intermediate metabolite of the adenosine triphosphate (ATP)dependent -glutamyl cycle, which is responsible for glutathione (GSH) synthesis

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