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10.1016/j.abb.2007.04.024 64 PetrashJ

It should be noted that the fold changes of these redox defects are much more pronounced than that of glutamate level decrease in SLC7A11 high cancer cells under glucose starvation, and thereby correlate better with the rapid and dramatic cell death observed in these cells upon glucose starvation (Liu et al., 2020)

It is oxidized to GSSG (and reduced again by glutathione reductase)

10.1016/j.mcpro.2023.100557 167 ShararN.WstefeldK.TalukderR

The molecules are large (polymeric DNA fragments ranging from kilodaltons into the megadalton range), highly polar, and have no realistic path across intact stratum corneum

By reassessing the effects of GSH within the context of MASLDs metabolic underpinnings, investigators can generate findings that are more applicable to contemporary diagnostic and therapeutic frameworks