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The efficacy of a second-generation derivative, omaveloxolone (RTA408), has recently been assessed in a preclinical model for diabetic chronic non-healing wounds [277] and, interestingly, omaveloxolone is now being tested in phase-II clinical trial for the Friedreichs ataxia (FRDA), a neurodegenerative condition in which NRF2 activation is suppressed [278, 279]

Selenium appears to have a significant protective effect against the harm and dysfunction brought on by excessive activation of the HPA axis

Pegylated phospholipid micelles induce endoplasmic reticulum-dependent apoptosis of cancer cells but not normal cells

Furthermore, data showing whether 'responders' had lower baseline concentrations of GSH or GSH:GSSG were not provided

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