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In terms of molecular mechanism, we also discussed the role of endogenous (enzymatic, and non-enzymatic) and exogenous antioxidants (vitamins, plant-derived and other small molecules), including ascorbic acids, -carotene, -tocopherol, -lipoic acid, coenzyme Q10, melatonin, and flavonoids (quercetin, luteolin, kaempferol, epicatechin, catechin, daidzein, genistein, and rutin, etc.) in scavenging of ROS

The b12 injection benefits for females tend to be particularly pronounced because women are statistically more likely to present with B12 insufficiency, especially those who are pregnant, postpartum, perimenopausal, or following a plant-based diet

The model intracellular concentrations of Hcy, Met, and SAM all fall dramatically corresponding to the clinically observed declines in their plasma concentrations

PMID: 24696047

For each analyzed parameter, an assessment of possible outliers was performed using the interquartile range, with any outliers excluded from the statistical calculations