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FOXO3 activation has been shown to induce MAFbx and MuRF1 transcription, stimulate catabolism and cause muscle wasting [55, 56]

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6 , 7 Carnitine metabolism is key to human TMAO production and 3 major bacterial metabolic pathways leading to TMA synthesis from dietary precursors were described 8 : a) anaerobic choline degradation by choline TMA-lyase

Edgar, R., Domrachev, M

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VC is necessary for carnitine biosynthesis