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There is a consensus that aging is associated with two key aspects: (i) the progressive decline of numerous physiological processes, such as the bodys ability to accurately regulate homeostasis, and (ii) the enhanced risk of developing severe diseases such as cancer or cardiovascular disease

J Am Coll Nutr 5 : 137151

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Conversely, if there is no evidence of pituitary damage and ACTH levels are normal, but there is a hyporesponsiveness of the HPA axis, it would be prudent to consider other treatment options before resorting to prolonged corticosteroid use

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Fox et al., 2001