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Outcomes relied on caregiver-reported behavioral and sleep questionnaires (CBCL, TBAQ-SF, Vineland-2, CSHQ, BISQ), analyzed using mixing effects regression models

Lastly, while APOE effects dominated brain profiles, sex effects were more prominent in the periphery, which was also in accordance with a previous study in older (16 months old) APOE-TR mice (Shang et al., 2020), suggesting that regardless of age APOE has a major effect on brain bioenergetics