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The responsible clinical approach is to titrate slowly, evaluate response at each stage with monitoring, and stop increasing when results are adequate rather than when the theoretical maximum has been reached

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Treatment of cultures with B12 increased methylation levels of CpGs at chr17: 36,090,097 in MOD subjects and at chr17: 36,090,097, 36,090,102 and 36,090,246 in SEV subjects compared to their respective cultures at endpoint A

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