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It is located within the National Reserve Fauna Andean Eduardo, in the highlands in the department of Potos, near the border with Chile

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High doses may cause temporary headaches due to increased NAD+ turnover and mitochondrial activity

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Because previous studies have demonstrated that NAD + depletion can induce cellular senescence, while the senescence associate secretory phenotype (SASP) in turn can induce CD38 26,27 , it was important to examine the impact of Ab68 on p21, a widely used albeit non-specific marker of cellular senescence