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Altering the PUFA composition of dopaminergic neuronal membranes and co-treating with iron can synergistically amplify lipid peroxidation and trigger ferroptosis, which has been confirmed in LUHMES cell and mouse organotypic brain slice experiments (70)

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If the reason is less clear, the care team may recommend review of symptoms, outside records, or broader follow-up before turning B12 into a repeating plan

Higher amounts rarely add benefit and can sometimes feel sticky or less comfortable

doi: 10.1097/FBP.0000000000000613