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While the precise etiology remains incompletely understood, central obesity and insulin resistance (IR) stand prominently as pivotal contributors to MetS onset

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When serum B12 is normal but MMA is elevated, this may indicate a functional B12 deficiency and may be treated with high-dose injections of vitamin B12, which help bypass barriers to absorption

After a median follow-up of 16.9 months, the addition of daratumumab to Kd yielded a statistically significant improvement in median PFS (HR, 0.63

Some patients may experience transient changes in blood pressure, though long-term cardiovascular outcomes studies have generally shown beneficial or neutral effects of GLP-1 receptor agonists on cardiovascular events