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These compounds act on repair, inflammation, and stress response pathways that do not fit the single-indication logic of FDA drug approval

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In addition to our literature review, an animal model study has shown that amlodipine inhibits AGEs deposition in the inner membrane of the aorta, despite the absence of a statin effect on plasma lipids 97

Thus an important reaction of H 2 O 2 with (free or poorly liganded) Fe(II) is the Fenton reaction (208,212,213) , leading to the very reactive and damaging hydroxyl radical (OH ): which can react within nanoseconds with anything adjacent

Additionally, the mechanism by which PNPLA3 inhibited lipolysis involved the re-esterification of mobilized FAs (Figure 1)