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Using the code E11.3511 as an example: E11 = Type 2 diabetes mellitus .35 = with proliferative diabetic retinopathy 1 = with macular edema 1 = right eye Five distinct clinical facts in seven characters

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There is also an increased sensitization of the excitatory neurotransmitter system, such as NMDA glutamate receptors, the reduction in the number of GABA receptors (downregulation), the shift of benzodiazepine receptors to an inverse agonist state, and compensatory changes in other components of the macromolecular GABA/benzodiazepine/chloride ionophore complex (for review see, i.e., [219,220,221,222,223,224,225])

Peptides are short chains of amino acids, the building blocks of proteins

Patulin regulates the expression of genes and proteins involved in mitochondrial ETC, resulting in dysfunction of OXPHOS and induction of ROS overproduction