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In the pregnant rat (30 rats per group), twice-daily exposure to an aerosol of acetylcysteine solution and isoproterenol for 30 or 35 minutes from the 15th day of gestation through the 21st day postpartum was without adverse effect on dams or newborns

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ALC counteracts oxidative stress and senescence by up-regulating Heat-shock proteins, Nrf2 signalling, HO-1, and SOD and promotes the transcription of the Grm2 gene [158, 166, 167, 170, 185]

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65 Interestingly, Auranofin-induced H 2 O 2 inhibits cyclin D-CDK4/6 activity by inducing disulfide bond formation between CDK4 and cyclin D, reducing cell proliferation

These oxidative dynamics are shown to modulate the sensitivity of CICD cells to stress conditions and the fate of cancer cells