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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region

Jama 323 , 11751183 (2020)

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Increasing evidence has demonstrated that in response to hypoxia, tubular epithelial cells undergo changes and function as inflammatory and fibrogenic cells (they may undergo tubular epithelial cell death/atrophy, maladaptive repair, metabolism switch, senescence, etc.), with the consequent production of various bioactive molecules that drive interstitial inflammation and fibrosis