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For instance, nucleic acid drugs are prone to enzymatic degradation

The key mechanisms involve: (1) enhancement of antioxidant defense systems via the activation of NRF2, GPX4, and SLC7A11

Negoro E, Radivoyevitch T, Polprasert C, Adema V, Hosono N, Makishima H, et al

Homocysteine transport into systemic circulation enables a normal Hcy flux through the trans-sulfuration pathway, which would explain normal GSH levels in our cohort of vitamin B 12 deficient patients

References 1.Hanahan D., Weinberg R.A