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4 Interestingly, Pearson syndrome can evolve into Leigh syndrome or Kearns-Sayre syndrome over time, 352,353 indicating that the phenotype of an mtDNA deletion disorder may change with age and is influenced by the concentration of mtDNA with deletions

doi: 10.1016/j.medcle.2020.06.010 41 ChenTSongJLiuHZhengHChenC

Finally, the biomedical research data should be used to educate the public including MDMA users about the potential harms of MDMA use especially in conjunction with other abused substances including alcohol

10.1016/j.jare.2023.11.021 J

by targeting pro-inflammatory factors and reducing the abnormal activation of microglia, the damage caused by an overactive immune response in the central nervous system to neuronal cells can be mitigated (13)