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A role for this protein in repair of DNA double-strand breaks has also been suggested.[211] Pathogenic variants in similar DNA helicases lead to the inherited disorders of Bloom syndrome and Werner syndrome

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The most common initial forms of CLE were generalized discoid lupus and panniculitis, significantly overrepresented compared to the rest of the cohort (Table 2)

3 In addition, carnitine may aid fat metabolism by increasing the transfer of acyl-CoA enzymes from mitochondria, which may further enhance the formation and transfer of fatty acids