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To mitigate IGF-1 side effects such as joint pain, swelling, and nerve compression, bodybuilders can follow several strategies: use the lowest effective dose under medical supervision, rotate injection sites, maintain proper hydration, support joints with supplements like glucosamine or omega-3 fatty acids, and incorporate stretching and mobility exercises

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Lipoic acid decreases exhaled nitric oxide concentrations in anesthetized endotoxemic rats

Cozzolino M, Vitagliano A

But it's a powerful remodelling signal and flooding your face with remodelling signals daily is not the same as skincare