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A static representation of the topology and electrostatic field in the H-site (Warshel, 1998) will have to be complemented with a description of the dynamics of the entire molecule ( Substrate Discrimination in Promiscuous Enzymes GSTs, like many other enzymes involved in detoxication, are promiscuous such that they can act on several different substrates and catalyze many alternative chemical reactions

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10.1111/j.1476-5381.2011.01480.x Br J Pharmacol

Proc Natl Acad Sci USA 107:23312336 Maurya AK, Agarwal R, Gupta R (2025) Unraveling the crosstalk among ethylene, nitric oxide, and polyamines in tailoring the abiotic stress resilience in plants

J Mol Struct 1244:130989

Increased ALOX5 expression elevated leukotriene B4 levels, promoted M1 macrophage polarization, and worsened cardiac injury, whereas ALOX5 knockout or pharmacological inhibition with zileuton reduced inflammation, preserved cardiac function, and improved survival (Xie et al., 2021)