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RIPK3 and RIPK1 mediate the formation of a necrosome complex, which primarily mediates necroptosis (Morgan and Kim 2022)

Currently, no therapeutic intervention is available as neuroprotective treatment for TBI

LLPS has been implicated in cancer and many neurodegenerative diseases, such as Alzheimers disease (AD), ALS, and frontotemporal dementia (FTD) 11,23,24,25,26,27

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Mitochondrial ROS in cancer: initiators, amplifiers or an achilles heel

Johnsen SP, Hundborg HH, Sorensen HT, Orskov H, Tjonneland A, Overvad K, Jorgensen JO: Insulin-like growth factor (IGF) I, -II, and IGF binding protein-3 and risk of ischemic stroke