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As with all supplements, some people should avoid milk thistle altogether, primarily individuals who are allergic or sensitive to Asteraceae and/or Compositae plants and those currently on medications that may severely interact with silymarin (e.g., deferiprone or simeprevir)
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Ischemia and hypoxia can disrupt the microbial composition of the gut microbiome, which can lead to intestinal barrier dysfunction and bacterial translocation [12]

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