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Exposure of embryonic hippocampal neurons to the morphogen Sonic Hedgehog increases mitochondrial mass during axonal outgrowth 36,37 , while activation of mitochondrial biogenesis in embryonic cortical neurons coincides with neuritogenesis 38,39

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Its research profile makes it especially relevant for studies focused on fat-cell pathway models, metabolic turnover, energy-balance signaling, methylation-adjacent biology, and body-composition pathway research

Recalibrating the epigenetic clock: implications for assessing biological age in the human cortex

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