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NAC at pH higher than its pKa can penetrate the biofilm matrix and eventually kill 100% of the bacteria embedded in the biofilm [52,53]

Here is the summary for the preparation and most common reactions of amides, which you can use to work on the practice problems:

The most common adverse reactions in patients with sickle cell disease or other anemias (incidence 6%) are pyrexia, abdominal pain, bone pain, headache, vomiting, pain in extremity, sickle cell anemia with crisis, back pain, ALT increased, AST increased, arthralgia, oropharyngeal pain, nasopharyngitis, neutrophil count decreased, cough and nausea