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Cell death mechanisms of neurodegeneration
Similar content being viewed by others Introduction Compared with antibodies, peptides exhibit certain disadvantages, such as lower affinity, rapid excretion from the body (or shorter half-life in the body), and vulnerability to protease-mediated degradation
Mitochondrial fusion (mediated by Mitofusin 1/2 (MFN1/2) and optic atrophy 1 (OPA1)) and fission (regulated by dynamin-related protein 1 (DRP1) and fission 1 (Fis1)) maintain dynamic equilibrium, but this balance is disrupted in PD [202]
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Similarly, exosomes from ASCs protect H9c2 cardiomyocytes from HO-induced damage by reducing apoptosis and hypertrophy in vitro 156
