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195,198 Bioactive compounds, including baicalin, chrysin, curcumin, genistein, hesperetin, kaempferol, quercetin, tangeretin, and taxifolin have demonstrated efficacy as immunomodulators and in treating autoimmune diseases

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Agents such as SMAC mimetics, HDAC inhibitors, and proteasome inhibitors (e.g., bortezomib) can modulate necroptosis, and combination strategies with conventional therapies that induce stress pathways show promise (14, (13, 23)