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The pathogenesis of DD involves cellular events such as altered gene and protein expression of cytokines, growth factors, adhesion molecules, and components of the extracellular matrix, resulting in increased deposition of collagen III relative to collagen I levels [77,78]

Headaches, nausea, and dizziness that occur early in use usually diminish as the body adjusts

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Officially, the FDA cites: Insufficient large-scale clinical trials Concerns about consistency, sourcing, and manufacturing standards The need to meet formal drug approval requirements Critics argue (fairly) that this system: Favors large pharmaceutical companies Makes it hard to approve naturally occurring peptides Leaves promising, low-risk compounds in regulatory limbo The short version: This FDA restrictive regulatory change of mind wasnt driven by a sudden safety scare, it was driven by regulatory process and economics