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the most common MC1R variant promotes eumelanin production, but other germline variants are associated with increased pheomelanin and decreased eumelanin biosynthesis [6]

There is some evidence for the use of CCH in stable disease with curvature over 30 and with HA offering a potential role in active disease but this is subject to further research

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Cleft lip is occasionally associated with other birth defects or syndromes

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