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Description
The free hormone hypothesis proposes that hormones not bound to carrier proteins with high affinity can freely diffuse across cell membranes to perform their biological activities [13,34]

However, although this approach decreased tumour cell proliferation and, consequently, tumour volume in an NF1 mouse model, 42,43 mTOR inhibitors were ineffective against pNF in one clinical trial 44 but prolonged progression-free survival, albeit modestly, in another trial 45 (NCT00634270)

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10.4155/fmc-2022-0316 129 YadavS.NarasimhanB.KaurH

doi: 10.1080/01635581.2020.1817957 33 YamanMKayaGYekelerH

"A metabolic network in the evolutionary context: multiscale structure and modularity"
