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N Engl J Med 1997;337:1441-8

Established benefits of B12 therapy: Treatment of documented deficiency: Intramuscular hydroxocobalamin is the standard NHS treatment for pernicious anaemia and other causes of B12 deficiency, effectively reversing haematological and neurological complications

In animal-model work, NNMT inhibition with 5-Amino-1MQ has been associated with changes in adipose-tissue mass, in NAD+ pool sizes (because NNMT consumes nicotinamide that would otherwise feed the NAD+ salvage pathway), and in methyl-donor dynamics (because NNMT consumes S-adenosylmethionine)

Protein Expression and Signalling Analysis: Evaluating transcriptional and translational changes under controlled experimental conditions

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IK, MM, and KS obtained the resources